News

ACRE, July 7-9 2025

ACRE Canada : Academy of Cardiovascular Research Excellence

https://acrecanada.ca/events/3rd-acre-canada-meeting/

Conference Co-Chairs: Dr. Dake Qi (Pharmacy) and Dr. Garry Shen (Medicine), University of Manitoba

Local organizers: Dr. Jiming Kong (Anatomy and Cell Biology), Dr. Michael Czubryt (Physiology and Pathophysiology), and Dr. Sanjiv Dhingra (Physiology and Pathophysiology), University of Manitoba

Organizing Committee Members: Tianqing Peng and Qingping Feng (Western University), Ren-Ke Li and Burton Yang (U of Toronto), Dake Qi and Garry Shen (U of Manitoba), Guangdong Yang (Laurentian U), Dawei Zhang (U of Alberta), Ying Wang and Hong-Lin Luo (UBC), Xi-Long Zheng (U of Calgary), Wenbin Liang (U of Ottawa), Bernardo Trigatti (McMaster U).

Preliminary Conference Program

Monday, July 7, 2025

7:30 – 9:00 AM                      Conference Registration, and Poster Setup

Breakfast

9:00 – 9:15 AM                       Opening Remarks

Dr. Dake Qi, University of Manitoba

Dr. Bernardo Trigatti, President of CSATVB, McMaster University

Dr. Qingping Feng, President of ACRE Canada, Western University

9:15 – 9:20 AM                       Dr. Jude Uzonna, Vice Dean of Research, Rady Faculty of Health Sciences, University of Manitoba

SESSION I: Cell functions and heart disease

Co-Chairs: Bernardo Trigatti and Dake Qi

9:20 – 9:40 PM                       Wnt signaling and cardiac remodeling: ion channels and beyond

Dr. Wenbin Liang, University of Ottawa, Ottawa, ON, Canada

9:40 – 10:00 PM                     Multiplex imaging of human coronary lesions defines the phenotype of macrophages with impaired phagocytic activity

Dr. Ying Wang, University of British Columbia, Vancouver, BC, Canada

10:00 – 10:20 PM                   BRD4 in vascular aging: Understanding the epigenetic control of smooth muscle function

Dr. Xi-Long Zheng, University of Calgary, Calgary, AB, Canada

10:20 – 10:40 PM                   Unraveling the mechanism of myocarditis: Viral manipulation of autophagy

Dr. Honglin Luo, University of British Columbia, Vancouver, BC, Canada

10:40 – 11:10 AM                   Refreshment Break and Trainee Poster Presentation

SESSION II: Development, Cardiac Injury and Regeneration

Co-Chairs: Wenbin Liang and Yaozu Xiang

11:10 – 11:30 AM                   Maternal environment in embryonic heart development: Role of eNOS

Dr. Qingping Feng, Western University, ON, Canada

11:30 – 11:50 AM                   Cardiac stem cell therapy: Still a long road to go

Dr. Sanjiv Dhingra, University of Manitoba, Winnipeg, MB, Canada

11:50 – 12:10 PM                   TBA

Dr. Bernardo Trigatti

12:10 – 12:30 PM                   Type-dependent differences in cardiovascular remodeling under mechanical overload: A comparative study

Dr. Jian Wu, Zhongshan Hospital, Fudan University, Shanghai, China

12:30 – 2:00 PM                     Box lunch and trainee poster presentation

SESSION III: Trainee Oral Presentations

Co-Chairs: Dawei Zhang and Ying Wang

2:00 – 2:15 PM                       TBA

2:15 – 2:30 PM                       TBA

2:30 – 2:45 PM                       TBA

2:45 – 3:00 PM                       TBA

3:00 – 3:15 PM                       TBA

3:15 – 4:00 PM                       Refreshment Break and Trainee Poster Presentation

SESSION IV: Keynote Presentation I

Chair: Dr. Ren-Ke Li

4:00 – 4:40 PM                      Circadian dependent regulation of cellular quality control mechanisms in the heart

Keynote Speaker: Dr. Lorrie Kirshenbaum, University of Manitoba, Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechsen Research Centre, Winnipeg, MB, Canada

4:40 – 5:30 PM                       Trainee poster presentation

6:00 – 7:30 PM                      CSATVB and CAS member meeting, Room 800 JBRC (invited only)

Tuesday, July 8, 2025

SESSION V: Keynote Presentation II

Chair: Dr. Garry Shen

9:00 – 9:40 PM                       Shear stress and vascular inflammation

Keynote Speaker: Dr. Yu Huang, City University of Hong Kong, Hong Kong, China

SESSION VI: Trainee Oral Presentations

Co-Chairs: Guangdong Yang and Sanjiv Dhingra

9:40 – 9:55 AM                       TBA

9:55 – 10:10 AM                     TBA

10:10 – 10:25 AM                   TBA

10:25 – 10:40 AM                 Isovaleroylbinankadsurin A ameliorates atherosclerosis and restenosis by promoting LXRα and inhibiting TGF-β1 and FHL1 signaling pathways

Dr. Yaning Shi, PDF, Hunan University of Chinese Medicine, Changsha, China

10:40 – 11:10 AM                   Refreshment Break and Trainee Poster Presentation

SESSION VII: Smooth muscle and vascular diseases

Co-Chairs: Samantha Pauls and Heyu Ni

11:10 – 11:30 AM                   H2S regulation of iron homeostasis in smooth muscle cells

Dr. Guangdong Yang, Laurentian University, Sudbury, ON, Canada

11:30 – 11:50 AM                   Interplay of scleraxis and AngII regulates vascular smooth muscle phenotype and blood vessel structure

Dr. Michael Czubryt, University of Manitoba, Winnipeg, MB, Canada

11:50 – 12:10 PM                  Activation of endothelial Nrf2 prevents atherosclerosis in ApoE-/- mice by inhibiting inflammation and lipid peroxidation

Dr. Cheng-Lin Zhang, Shenzhen University Medical School, Shenzhen, China

12:10 – 12:30 PM                   Using PAR2 pathway-biased agonists to target specific endothelium-dependent vascular smooth muscle relaxation mechanisms in mouse arteries

Dr. John McGuire, Western University, London, ON, Canada

12:30 – 2:00 PM                     Box Lunch and Trainee Poster Presentation

SESSION VIII: Inflammation and metabolism

Co-Chairs: Michael Czubryt and Xi-Long Zheng

2:00 – 2:20 PM                       Impact of high nutrient loads and omega-3 fatty acids on monocyte metabolism and function

Dr. Samantha Pauls, University of Manitoba, Winnipeg, MB, Canada

2:20 – 2:40 PM                       HMOX1-LDHB interaction promotes ferroptosis by inducing mitochondrial dysfunction in foamy macrophages during advanced atherosclerosis

Dr. Jinwei Tian, Harbin Medical University, 2nd Affiliated Hospital, Harbin, China

2:40 – 3:00 PM                       Heart under stress: The impact of gestational diabetes on mitochondrial protein acetylation

Dr. Vernon Dolinsky, University of Manitoba, Winnipeg, MB, Canada

3:00 – 3:20 PM                       Gut hormones in the regulation of intestinal lipids

Dr. Changting Xiao, University of Saskatchewan, SK, Canada

3:20 – 4:00 PM                       Refreshment Break and Trainee Poster Presentation

SESSION IX: Potential therapeutic strategies for cardiac diseases

Co-Chairs: Honglin Luo and Qingping Feng

4:00 – 4:20 PM                       Strategies for rebalancing hematopoiesis against myocardial infarction and heart failure

Dr. Yaozu Xiang, Tongji University, Shanghai, China

4:20 – 4:40 PM                       STAT3 signaling in conditioning cardioprotection in normal and functionally impaired heart

Dr. Zhengyuan Xia, University of Hong Kong, Hong Kong, China

4:40 – 5:00 PM                       TBA

TBA

5:00 – 5:20 PM                       Consideration of Perioperative management of end-stage heart disease: from evidence-based medicine to clinical practice

Dr. Sheng Wang, Anding Hospital, Capital Medical University, Beijing, China

5:20 – 6:00 PM                       Trainee Poster Presentation

6:00 – 9:00 PM                       Conference dinner

Wednesday, July 9, 2025

SESSION X: Gary Lopaschuk Memorial Lecture

Chair: Vernon Delinsky

9:00 – 9:50 AM                      The Role of Pyruvate Dehydrogenase & Glucose Oxidation in Cardiovascular Disease: A Tribute to Dr. Gary Lopaschuk

Dr. John Ussher, University of Alberta, Edmonton, Canada

9:50 – 10:30 AM                 Refreshments break and Trainee Poster Presentation

SESSION XI: Potential therapeutic strategies for vascular diseases

Co-Chairs: Changting Xiao and Zhengyuan Xia

10:30 – 10:50 AM                   Control of Heart Attack and Stroke – developing novel anti-platelet therapy against atherothrombosis

Dr. Heyu Ni, University of Toronto, ON, Canada

10:50 – 11:10 AM                   Anti-atherosclerotic effect and mechanism of Tripterygium wilfordii

Dr. Li Qin, Hunan University of Traditional Medicine, Changsha, China

11:10 – 11:30 AM                   Vascular protection in atherosclerosis: unveiling the potential of traditional Chinese medicine

Dr. Guanwei Fan, Tianjin University of Traditional Chinese Medicine, Tianjin, China

11:30 – 11:50 AM                   The influence of Saskatoon berry intake on metabolism and vascular function in healthy humans: relationship with gut microbiota and short chain fatty acids

Dr. Garry Shen, University of Manitoba, Winnipeg, MB, Canada

11:50 – 12:20 PM                   Trainee Presentation Award Ceremony

Group Photo of Awardees

12:20 – 12:30 PM                   Closing Remarks

Dr. Gary Shen, Conference Co-Chair, University of Manitoba

Dr. Ren-Ke Li, President-Elect, ACRE Canada

12:30 – 1:30 PM                     Lunch

1:30 – 2:30 PM                       ACRE Canada business meeting

2:30 PM                                   Conference ends